Immune responses in fatalities involving opioids
نویسندگان
چکیده
منابع مشابه
Four fatalities involving 5-IT.
The new designer drug 5-(2-aminopropyl)indole (5-IT) is an indole derivative with stimulant properties. Its synthesis was first described by Albert Hofmann and Franz Troxler in 1962. We report four deaths associated with 5-IT and a validated high-performance liquid chromatography method for quantitation of the drug. In all four deaths, an autopsy was performed, and femoral venous blood, heart b...
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Introduction ATVs are defined as off-road recreational vehicles that may or may not be permitted for use on public roadways depending on a wide range of State regulations. An ATV generally has three or more low-pressure tires, a straddle seat, a handlebar for steering, and hand controls for braking and acceleration. As with any vehicle, proper training and education are important when operating...
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In late pregnant rats, the hypothalamic-pituitary-adrenal (HPA) axis is hyporesponsive to psychogenic stressors. Here, we investigated attenuated HPA responses to an immune challenge and a role for endogenous opioids. ACTH and corticosterone were assayed in blood samples from virgin and 21 d pregnant rats before and after endotoxin [lipopolysaccharide (LPS); 1 microg/kg, i.v.], interleukin-1bet...
متن کاملDifferent Immune Responses in Dangerous O Blood Donors
Background & Objective: Dangerous O is very important to transfusion medicine and there has been reports by Food and Drug Administration (FDA) regarding some death relating incidences. As high iso-antibody production is closely associated with different immune reactions, a survey on the different immune response of dangerous O donors can lead to understanding their immune respo...
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Morphine and other opioids have traditionally been thought to act as analgesics centrally, with effects at peripheral receptors accounting for wide-ranging adverse effects such as constipation and itching. Many opioid receptors have been found on immune cells, nerve endings, gut and other tissues, but until recently the nature of their roles and actions has been uncertain. Opioids are known to ...
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ژورنال
عنوان ژورنال: Forensic Sciences Research
سال: 2019
ISSN: 2096-1790,2471-1411
DOI: 10.1080/20961790.2018.1558503